Ph.D., M.Sc., B.Sc. (Distinction)

Research Assistant Professor

• Single-Cell and Spatial Biology
• Bioinformatics and Precision Medicine
• Cancer Biology and Therapy
• Scoliosis Screening and Treatment

Research postgraduate opportunities are available. Interested and dedicated students are encouraged to contact me.

Dr. Zezhuo SU currently serves as a Research Assistant Professor at the University of Hong Kong, having previously held roles as a Research Officer and Postdoctoral Fellow at the same institution, as well as at the Laboratory of Data Discovery for Health Limited. He earned his Ph.D. in Single-Cell Cancer Biology from the Department of Orthopaedics and Traumatology at the University of Hong Kong. He also holds an M.Sc. in Molecular Cell Biology and a B.Sc. in Biotechnology with distinction. As a dedicated interdisciplinary researcher in molecular cell biology and bioinformatics, Dr. Su aims to bridge the gap between clinicians and scientists to foster advancements in biomedical sciences. His expertise has significantly contributed to the understanding of cellular heterogeneity, disease progression, and the identification of biomarkers and therapeutic targets in orthopaedics and cancer research.

Papers in Progress

• Z. Su #, M. Yeung #, S. Han #, R. Yau, Y. L. Lam, Ho W. Y., T. Shek, F. Shi, S. Feng, H. Chen, J. Ho, Z. Xu, J. Cheung, K. Cheung. Denosumab Enhances anti-tumour Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells. Cancer Immunology Research. (In Press)
• Sun, Y.#, Peng, Y. #, Su, Z. #, So, K. H. K., Lu, Q. J., Lyu, M. J., Zou, J., Huang, Y., Guan, Z., Cheung, M. C. K. Zheng, Z., Zhang, X., Leung, V. Y. Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity. Bone Research. (In Press)
• S. Shen, T. Werner, S. W. Lukowski, S. Andersen, Y. Sun, W. J. Shim, D. Mizikovsky, S. Kobayashi, J. Outhwaite, H. S. Chiu, X. Chen, G. Chapman, E. M. M. A. Martin, D. Xia, D. Pham, Z. Su, D. Kim, P. Yang, M. C. Tan, E. Sinniah, Q. Zhao, S. Negi, M. A. Redd, J. E. Powell, S. L. Dunwoodie, P. P. L. Tam, M. Bodén, J. W. K. Ho, Q Nguyen, N. J. Palpant. Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure. Nature Communications. (Accepted)

Original Research Papers

• Su, Z. #, Ho, J. W. K. #, Yau, R. C. H., Lam, Y. L., Shek, T. W. H., Yeung, M. C. F., … & Cheung, K. S. C. (2024). A single-cell atlas of conventional central chondrosarcoma reveals the role of endoplasmic reticulum stress in malignant transformation. Communications Biology, 7(1), 124.
• K. Zhao, M. Zheng, Su, Z., S. Ghosh; C. Zhang, W. Zhong, G. Jin, J. Ho, Z. Zhou. MOF-mediated acetylation regulates SIRT6 tumor suppressive activity in non-small cell lung cancer. Cell Reports. 2023 Aug 29;42(8):112939.
• Sun, Y., Shim, W. J., Shen, S., Sinniah, E., Pham, D., Su, Z., Mizikovsky, D., White, D. M., Ho, W. K. Joshua, Nguyen Q., Bodén M., J. N. Palpant. (2023). Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity. Nucleic Acids Research, 51(11), e62-e62.
• Zhang, X., Dai, Y.S., Wang, Y.X., Su, Z.Z., Yu, L.J., Zhang, Z.F., Xiao, S. and Chen, Q.F., 2022. Overexpression of the Arabidopsis MACPF Protein AtMACP2 Promotes Pathogen Resistance by Activating SA Signaling. International journal of molecular sciences, 23(15), p.8784.
• Chen, M.X., Zhu, F.Y., Wang, F.Z., Ye, N.H., Gao, B., Chen, X., Zhao, S.S., Fan, T., Cao, Y.Y., Liu, T.Y., Su, Z.Z., Xie, L.J., Hu, Q.J., Wu, H.J., Xiao, S., Zhang, J.H. and Liu, Y.G., 2018. Alternative splicing and translation play important roles in parallel with transcriptional regulation during rice hypoxic germination. Journal of Experimental Botany, 70.3 (2019): 817-833.
• Ye, N.H., Wang, F.Z., Shi, L., Chen, M.X., Cao, Y.Y., Zhu, F.Y., Wu, Y.Z., Xie, L.J., Liu, T.Y., Su, Z.Z. and Xiao, S., 2018. Natural variation in the promoter of rice calcineurin B‐like protein10 (Os CBL 10) affects flooding tolerance during seed germination among rice subspecies. The Plant Journal, 94(4), pp.612-625.
• Zhu, F.Y., Chen, M.X., Ye, N.H., Qiao, W.M., Gao, B., Law, W.K., Tian, Y., Zhang, D., Zhang, D., Liu, T.Y., Hu, Q.J., Cao, Y.Y., Su, Z.Z., Zhang, J.H., and Liu, Y.G., 2018. Comparative performance of the BGISEQ-500 and Illumina HiSeq4000 sequencing platforms for transcriptome analysis in plants. Plant Methods, 14(1), p.69.
• Chen, L., Su, Z.Z., Huang, L., Xia, F.N., Qi, H., Xie, L.J., Xiao, S. and Chen, Q.F., 2017. The AMP-activated protein kinase KIN10 is involved in the regulation of autophagy in Arabidopsis. Frontiers in plant science, 8, p.1201.

Review Papers

• Xue, Y., Su, Z., Lin, X., Ho, M. K., & Yu, K. H. (2024). Single-cell lineage tracing with endogenous markers. Biophysical Reviews, 1-15.
• So, K., Su, Z., Cheung, J., & Choi, S. W. (2024). Single-Cell Analysis of Bone-Marrow-Disseminated Tumour Cells. Diagnostics, 14(19), 2172.
• B HUANG, Z JIA, C FU, M CHEN, Su, Z.* and Y CHEN*. (2024). Oncogenic and tumor-suppressive roles of LCN2 in tumor progression. Oncology Research. https://doi.org/10.32604/or.2024.051672
• Su, Z., Chen, Z., Ma, K., Chen, H. and Ho, J.W., 2022. Molecular determinants of intrinsic cellular stiffness in health and disease. Biophysical Reviews, pp.1-13.

Principle investigator

• Department Seed Fund, The University of Hong Kong; 2024
• Department Seed Fund, The University of Hong Kong; 2023

Co-Investigator

• SRS Cotrel Foundation Basic Science Research Grant; 2024
• Li Shu Pui Medical Foundation Research Grants; 2023
• Health and Medical Research Fund; 2022

Principal Member

• Natural Science Fund of Guangdong Province; 2024
• Natural Science Fund of Guangdong Province; 2023
• Shenzhen-Hong Kong-Macau Technology Research Programme Type C; 2021

PhD Project

• Health and Medical Research Fund; 2019
• General Research Fund; 2019

(Last Updated: January 11, 2025)