Biography

ZHU, Yizhou

ZHU, Yizhou

Research Assistant Professor

Honorary Assistant Research Fellow, Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, the University of Hong Kong Shenzhen Hospital

Research Interests

  • Immunomodulatory biomaterials
  • Ultrasound-responsive antibacterial biomaterials
  • Non-antibiotic antimicrobial strategies
  • Interface engineering for tissue regeneration

Biography

Currently, Dr. Zhu is a Research Assistant Professor at the Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong (HKU). His specializations include advanced tissue regeneration and antibacterial biomaterials, with a focus on surface engineering strategies for immune-modulating implants, nanomaterials engineering with stimulus-responsive platforms for tissue regeneration, and non-antibiotic antibacterial materials.

His academic contributions include 17 published papers with over 1000 citations and an h-index of 13 (Google Scholar). He has also actively participated in numerous local and regional competitions, earning recognition such as the Faculty Research Output Award (2024) and the Chinese Association for Biomaterials Trainee Award (2025). As both a principal investigator and co-investigator, he has successfully secured funding exceeding HK$ 7,000,000.

Publications (A total of 17 peer-reviewed journal papers with 1054 total citations; h-index:13):

(Five most representative publications in recent five years)

  1. Yizhou Zhu, Chaofeng Wang, Can Ai, Yiming Xiang, Congyang Mao, Wei Qiao, Jun Wu, John Akrofi Kubi, Xiangmei Liu*, Shuilin Wu*, Xin Zhao, Bin Li, Kelvin W. K. Yeung*. Photocurrent-directed immunoregulation accelerates osseointegration through activating calcium influx in macrophages, Advanced Functional Materials 34, 2406095 (2024) (IF: 18.5, 21/438 in Materials Science, Multidisciplinary).
  2. Yizhou Zhu, Hang Liang, Xiangmei Liu*, Jun Wu, Cao Yang*, Tak Man Wong, Kenny Y. H. Kwan, Kenneth M. C. Cheung, Shuilin Wu, Kelvin W. K. Yeung*. Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration, Science Advances 7,eabf6654 (2021).(IF: 11.7,11/134 in Multidisciplinary Sciences Citation:282, highly cited paper: top 1% of the academic field of Materials Science).
  3. Yizhou Zhu, Wanglong Hong, Xiangmei Liu*, Lei Tan, Jun Wu, Caoyang Mao, Yiming, Xiang, Shuilin Wu*, Kenneth M. C. Cheung, and Kelvin W. K. Yeung*. Rapid bacterial elimination achieved by sonodynamic Au@Cu2O hybrid nanocubes. Nanoscale 13, 15699-15710 (2021). (IF:5.8, 109/438 in Materials Science, Multidisciplinary, Citation: 46)
  4. Yiming Xiang, Jiali Lu, Congyang Mao, Yizhou Zhu, Chaofeng Wang, Jun Wu, Xiangmei Liu*, Shuilin Wu*, Kenny Y. H. Kwan, Kenneth M. C. Cheung, Kelvin W. K. Yeung* Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Science Advances, 9(10): eadf0854 (2023) (IF: 11.7, 11/134 in Multidisciplinary Sciences Citation: 81, highly cited paper: top 1% of the academic field of Materials Science)
  5. Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Yufeng Zheng, Kenneth M. C. Cheung, and Kelvin Wai Kwok Yeung*. Realizing highly efficient sonodynamic bactericidal capability through the phonon–electron coupling effect using two-dimensional catalytic planar defects. Advanced Materials 2208681 (2023) (IF: 27.4, 11/438 in Materials Science, Multidisciplinary, Citation: 36)

(Five representative publications beyond the recent five years, #shared the first authorship)

  1. Yizhou Zhu, Xiangmei Liu Jun Wu, Tak Man Wong, Xiaobo Feng, Cao Yang, Shuilin Wu, Yufeng Zheng, Xuanyong Liu, Kenneth M. C. Cheung, and Kelvin W. K. Yeung*. Micro- and nanohemispherical 3D imprints modulate the osteogenic differentiation and mineralization tendency of bone cells. ACS Applied Materials & Interfaces 11, 35513-35524 (2019). (IF:8.3, 69/438 in Materials Science, Multidisciplinary, Citation: 18)
  2. Yizhou Zhu, Xiangmei Liu, Kelvin W. Yeung, Paul K. Chu, Shuilin Wu*. Biofunctionalization of carbon nanotubes/chitosan hybrids on Ti implants by atom layer deposited ZnO nanostructures. Applied Surface Science 400, 14-23 (2017) (IF: 6.3, 3/23 in Materials Science, Coatings & Films, Citation: 116)
  3. Kejia Zhang#, Yizhou Zhu#, Xiangmei Liu, Zhenduo Cui, XianjinYang, Kelvin W. K. Yeung, Haobo Pan, Shuilin Wu*. Sr/ZnO doped titania nanotube array: An effective surface system with excellent osteoinductivity and self-antibacterial activity. Materials & Design 130, 403-412 (2017) (IF:7.6, 80/438 in Materials Science, Multidisciplinary, Citation: 51)
  4. Tian Zhou, Yizhou Zhu, Xia Li, Xiangmei Liu*, Kelvin W. K. Yeung, Shuilin Wu*, Xianbao Wang, Zhenduo Cui, Xianjin Yang, Paul K. Chu. Surface functionalization of biomaterials by radical polymerization. Progress in Materials Science 83, 191-235 (2016). (IF: 33.6, 7/438 in Materials Science, Multidisciplinary, Citation: 157).
  5. Xiangmei Liu, Man Li, Yizhou Zhu, Kelvin W. K. Yeung, Paul K. Chu, Shuilin Wu*. The modulation of stem cell behaviors by functionalized nanoceramic coatings on Ti-based implants. Bioactive Materials 1, 65-76 (2016) (IF: 18.0, 1/53 in Materials Science, Biomaterials, Citation: 37).

(*These authors equally shared corresponding authorship and # shared the 1st authorship)

Grants

  • Health and Medical Research Fund, 1,448,090 HKD, Principal Investigator
  • Health and Medical Research Fund, 1,387,950 HKD, Co-investigator
  • Research Grants Council General Research Fund, 1,121,404 HKD, Co-investigator
  • Research Talent Hub for ITF Projects, 601,967 HKD, Co-investigator
  • Research Talent Hub for ITF Projects, 603,300 HKD, Co-investigator
  • Partnership Research Programme, 1,989,500 HKD, Co-investigator
  • Research Talent Hub for ITF Projects, 249,067 HKD, Co-investigator

Professional Societies

07/2022-present: Member. International Chinese Musculoskeletal Research Society

01/2025-present: Member. Chinese Association for Biomaterials (CAB)

Honours & Awards

2025: Trainee Award, Chinese Association for Biomaterials (CAB)

2024: Faculty Outstanding Research Output Award, LKS Faculty of Medicine, The University of Hong Kong

Invited Lectures & Keynote Speeches

31 July 2021: 材料表面形貌设计与巨噬细胞极化并促进骨-植入体界面整合的研究. 第二届宁波医疗器械产业技术论坛 (29/07/2021-31/07/2021, Ningbo, China).

13 January 2024: Regulation of cellular behaviors of macrophages and osteoblastic cells through surface topography design to facilitate implant-to-bone integration. Hong Kong Advanced Biomaterials Conference 2024 (12/01/2024-13/012024, Hong Kong, China)

[Updated on 14th February 2025]